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Graphical contents list • CONTENTS LIST PDF (1193 K) | |||
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2-(4-Methoxyphenoxy)-5-nitro-N-(4-sulfamoylphenyl)benzamide activates Kir6.2/SUR1 KATP channels • SHORT COMMUNICATION Flemming E. Nielsen, Palle Jacobsen, Anne Worsaae, Per O.G. Arkhammar, Philip Wahl and John Bondo Hansen SummaryPlus | Full Text + Links | PDF (269 K) | |||
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In vitro advanced antimycobacterial screening of cobalt(II) and copper(II) complexes of fluorinated isonicotinoylhydrazones • SHORT COMMUNICATION Rosanna Maccari, Rosaria Ottanà, Bruno Bottari, Enrico Rotondo and Maria Gabriella Vigorita SummaryPlus | Full Text + Links | PDF (254 K) | |||
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Expanding the scope of site-specific protein biotinylation strategies using small molecules • SHORT COMMUNICATION Lay-Pheng Tan, Grace Y.J. Chen and Shao Q. Yao SummaryPlus | Full Text + Links | PDF (332 K) | |||
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Haloperidol: towards further understanding of the structural contributions of its pharmacophoric elements at D2-like receptors • SHORT COMMUNICATION Donald M.N. Sikazwe, Shouming Li, Leroy Mardenborough, Vivian Cody, Brian L. Roth and Seth Y. Ablordeppey SummaryPlus | Full Text + Links | PDF (274 K) | |||
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Site-specific PEGylation of proteins containing unnatural amino acids • SHORT COMMUNICATION Alexander Deiters, T. Ashton Cropp, Daniel Summerer, Mridul Mukherji and Peter G. Schultz SummaryPlus | Full Text + Links | PDF (288 K) | |||
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α–β Chimeric oligo-DNA bearing intercalator-conjugated nucleobase inside the linker sequence remarkably improves thermal stability of an alternate-stranded triple helix • SHORT COMMUNICATION A.T.M. Zafrul Azam, Minoru Hasegawa, Tomohisa Moriguchi and Kazuo Shinozuka SummaryPlus | Full Text + Links | PDF (336 K) | |||
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Novel 2-oxoimidazolidine-4-carboxylic acid derivatives as Hepatitis C virus NS3-4A serine protease inhibitors: synthesis, activity, and X-ray crystal structure of an enzyme inhibitor complex • SHORT COMMUNICATION Ashok Arasappan, F. George Njoroge, Tejal N. Parekh, Xiaozheng Yang, John Pichardo, Nancy Butkiewicz, Andrew Prongay, Nanhua Yao and Viyyoor Girijavallabhan SummaryPlus | Full Text + Links | PDF (308 K) | |||
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Synthesis and cytotoxic activity of substituted Luotonin A derivatives • SHORT COMMUNICATION Sabrina Dallavalle, Lucio Merlini, Giovanni Luca Beretta, Stella Tinelli and Franco Zunino SummaryPlus | Full Text + Links | PDF (303 K) | |||
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Carbonic anhydrase inhibitors. Interaction of isozymes I, II, IV, V, and IX with phosphates, carbamoyl phosphate, and the phosphonate antiviral drug foscarnet • SHORT COMMUNICATION Stefano Rusconi, Alessio Innocenti, Daniela Vullo, Antonio Mastrolorenzo, Andrea Scozzafava and Claudiu T. Supuran SummaryPlus | Full Text + Links | PDF (281 K) | |||
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Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions • SHORT COMMUNICATION Alessio Innocenti, Michael A. Firnges, Jochen Antel, Michael Wurl, Andrea Scozzafava and Claudiu T. Supuran SummaryPlus | Full Text + Links | PDF (274 K) | |||
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Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with sulfonamides derived from 4-isothiocyanato-benzolamide • SHORT COMMUNICATION Alessandro Cecchi, Jean-Yves Winum, Alessio Innocenti, Daniela Vullo, Jean-Louis Montero, Andrea Scozzafava and Claudiu T. Supuran SummaryPlus | Full Text + Links | PDF (294 K) | |||
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Carbonic anhydrase inhibitors. Design of anticonvulsant sulfonamides incorporating indane moieties • SHORT COMMUNICATION Celine Chazalette, Bernard Masereel, Stéphanie Rolin, Anne Thiry, Andrea Scozzafava, Alessio Innocenti and Claudiu T. Supuran SummaryPlus | Full Text + Links | PDF (283 K) | |||
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Synthesis of new N-(2-(trifluoromethyl)pyridin-4-yl)anthranilic acid derivatives and their evaluation as anticancer agents • SHORT COMMUNICATION Maria T. Cocco, Cenzo Congiu, Valentina Lilliu and Valentina Onnis SummaryPlus | Full Text + Links | PDF (266 K) | |||
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Urea derivatives of STI571 as inhibitors of Bcr-Abl and PDGFR kinases • SHORT COMMUNICATION Paul W. Manley, Werner Breitenstein, Josef Brüggen, Sandra W. Cowan-Jacob, Pascal Furet, Jürgen Mestan and Thomas Meyer SummaryPlus | Full Text + Links | PDF (321 K) | |||
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Inactivation of S-adenosylhomocysteine hydrolase with haloethyl and dihalocyclopropyl esters derived from homoadenosine-6′-carboxylic acid • SHORT COMMUNICATION Georges Guillerm, Murielle Muzard and Cédric Glapski SummaryPlus | Full Text + Links | PDF (287 K) | |||
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Inactivation of human S-adenosylhomocysteine hydrolase by covalent labeling of cysteine 195 with thionucleoside derivatives • SHORT COMMUNICATION Georges Guillerm, Murielle Muzard, Cédric Glapski and Serge Pilard SummaryPlus | Full Text + Links | PDF (375 K) | |||
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Synthesis of small molecule CDC25 phosphatases inhibitors • SHORT COMMUNICATION Marie-Odile Contour-Galcéra, Olivier Lavergne, Marie-Christine Brezak, Bernard Ducommunand Grégoire Prévost SummaryPlus | Full Text + Links | PDF (257 K) | |||
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Design, synthesis, and evaluation of hexahydrobenz[f]isoquinolines as a novel class of dopamine 3 receptor ligands • SHORT COMMUNICATION Xihan Wu, Jianyong Chen, Min Ji, Judith Varady, Beth Levant and Shaomeng Wang SummaryPlus | Full Text + Links | PDF (265 K) | |||
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Chlorothiophenecarboxamides as P1 surrogates of inhibitors of blood coagulation factor Xa • SHORT COMMUNICATION Werner W.K.R. Mederski, Bertram Cezanne, Christoph van Amsterdam, Karl-Ulrich Bühring, Dieter Dorsch, Johannes Gleitz, Joachim März and Christos Tsaklakidis SummaryPlus | Full Text + Links | PDF (277 K) | |||
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Homology model of the multidrug transporter LmrA from Lactococcus lactis • SHORT COMMUNICATION Karin Pleban, Antonio Macchiarulo, Gabriele Costantino, Roberto Pellicciari, Peter Chiba and Gerhard F. Ecker SummaryPlus | Full Text + Links | PDF (360 K) | |||
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Synthesis and α4β2 nicotinic affinity of 2-pyrrolidinylmethoxyimines and prolinal oxime ethers • SHORT COMMUNICATION Marco Pallavicini, Barbara Moroni, Cristiano Bolchi, Francesco Clementi, Laura Fumagalli, Cecilia Gotti, Silvia Vailati, Ermanno Valoti and Luigi Villa SummaryPlus | Full Text + Links | PDF (279 K) | |||
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Screening of antimicrobial activity of diarylamines in the 2,3,5-trimethylbenzo[b]thiophene series: a structure–activity evaluation study • SHORT COMMUNICATION Isabel C.F.R. Ferreira, Ricardo C. Calhelha, Letícia M. Estevinho and Maria-João R.P. Queiroz SummaryPlus | Full Text + Links | PDF (244 K) | |||
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Ring nitrogen-substituted non-steroidal estrogens: pyridine and pyrimidine analogs of the phenol in deoxyhexestrol experience resonance constraints on preferred ligand conformation • SHORT COMMUNICATION Meri De Angelis and John A. Katzenellenbogen SummaryPlus | Full Text + Links | PDF (330 K) | |||
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Synthesis and biological studies of 1-amino β-carbolines • SHORT COMMUNICATION Yohan Boursereau and Iain Coldham SummaryPlus | Full Text + Links | PDF (277 K) | |||
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Evaluation of by disubstituted acridone derivatives as telomerase inhibitors: the importance of G-quadruplex binding • SHORT COMMUNICATION R. John Harrison, Anthony P. Reszka, Shozeb M. Haider, Barbara Romagnoli, James Morrell, Martin A. Read, Sharon M. Gowan, Christopher M. Incles, Lloyd R. Kelland and Stephen Neidle SummaryPlus | Full Text + Links | PDF (292 K) | |||
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3-O-Glutaryl-dihydrobetulin and related monoacyl derivatives as potent anti-HIV agents • SHORT COMMUNICATION Yoshiki Kashiwada, Michiko Sekiya, Yasumasa Ikeshiro, Toshihiro Fujioka, Nicole R. Kilgore, Carl T. Wild, Graham P. Allaway and Kuo-Hsiung Lee SummaryPlus | Full Text + Links | PDF (264 K) | |||
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Anti-AIDS agents. Part 62: Anti-HIV activity of 2′-substituted 4-methyl-3′,4′-di-O-(−)-camphanoyl-(+)-cis-khellactone (4-methyl DCK) analogs • SHORT COMMUNICATION Qian Zhang, Ying Chen, Peng Xia, Yi Xia, Zheng-Yu Yang, Donglei Yu, Susan L. Morris-Natschke and Kuo-Hsiung Lee SummaryPlus | Full Text + Links | PDF (258 K) | |||
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Determination of the free radical scavenging activity of dihydropyran-2,4-diones • SHORT COMMUNICATION Laura Cristiane de Souza, Stella Maris Soares de Araújo and Dennis de Oliveira Imbroisi SummaryPlus | Full Text + Links | PDF (268 K) | |||
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The impact of spacer structure on 5-HT7 and 5-HT1A receptor affinity in the group of long-chain arylpiperazine ligands • SHORT COMMUNICATION Andrzej J. Bojarski, Beata Duszyńska, Marcin Kołaczkowski, Piotr Kowalski and Teresa Kowalska SummaryPlus | Full Text + Links | PDF (326 K) | |||
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Allosteric potentiators of the metabotropic glutamate receptor 2 (mGlu2). Part 2: 4-Thiopyridyl acetophenones as non-tetrazole containing mGlu2 receptor potentiators • SHORT COMMUNICATION Anthony B. Pinkerton, Rowena V. Cube, John H. Hutchinson, Joyce K. James, Michael F. Gardner, Hervé Schaffhauser, Blake A. Rowe, Lorrie P. Daggett and Jean-Michel Vernier SummaryPlus | Full Text + Links | PDF (278 K) | |||
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Synthesis and biological evaluation of an orally active ghrelin agonist that stimulates food consumption and adiposity in rats • SHORT COMMUNICATION Charles W. Lugar, Michael P. Clay, Terry D. Lindstrom, Andrea L. Woodson, David Smiley, Mark L. Heiman and Jeffrey A. Dodge SummaryPlus | Full Text + Links | PDF (281 K) | |||
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Farnesyl protein transferase inhibitors targeting the catalytic zinc for enhanced binding • SHORT COMMUNICATION F. George Njoroge, Bancha Vibulbhan, Patrick Pinto, Corey Strickland, Paul Kirschmeier, W. Robert Bishop and V. Girijavallabhan SummaryPlus | Full Text + Links | PDF (367 K) | |||
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Tetrahydroisoquinoline derivatives as melatonin MT2 receptor antagonists • SHORT COMMUNICATION George N. Karageorge, Stephen Bertenshaw, Lawrence Iben, Cen Xu, Nathan Sarbin, Anthony Gentile and Gene M. Dubowchik SummaryPlus | Full Text + Links | PDF (254 K) | |||
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Synthesis and biological evaluation of novel taxoids designed for targeted delivery to tumors • SHORT COMMUNICATION Erkan Baloglu, Michael L. Miller, Elizabeth E. Roller, Emily E. Cavanagh, Barbara A. Leece, Victor S. Goldmacher and Ravi V.J. Chari SummaryPlus | Full Text + Links | PDF (301 K) | |||
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Binding of an aminoacridine derivative to a GAAA RNA tetraloop • SHORT COMMUNICATION Zhaohui Yan and Anne M. Baranger SummaryPlus | Full Text + Links | PDF (340 K) | |||
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Synthesis and inhibitory effects of pinosylvin derivatives on prostaglandin E2 production in lipopolysaccharide-induced mouse macrophage cells • SHORT COMMUNICATION Eun-Jung Park, Hye-Young Min, Yong-Hyun Ahn, Cheol-Man Bae, Jae-Ho Pyee and Sang Kook Lee SummaryPlus | Full Text + Links | PDF (277 K) | |||
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Bridgehead modification of trihalocycloheptabenzopyridine lead to a potent farnesyl protein transferase inhibitor with improved oral metabolic stability • SHORT COMMUNICATION F. George Njoroge, Bancha Vibulbhan, Xiongwei Shi, Corey Strickland, Paul Kirschmeier, Robert Bishop, Amin Nomeir and Viyyoor Girijavallabhan SummaryPlus | Full Text + Links | PDF (300 K) | |||
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Syntheses of photolabile novobiocin analogues • SHORT COMMUNICATION Gang Shen, Xiao ming Yu and Brian S.J. Blagg SummaryPlus | Full Text + Links | PDF (267 K) | |||
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Synthesis of analogs of (1,4)-3- and 5-imino oxazepane, thiazepane, and diazepane as inhibitors of nitric oxide synthases • SHORT COMMUNICATION K. Shankaran, Karla L. Donnelly, Shrenik K. Shah, Charles G. Caldwell, Ping Chen, William K. Hagmann, Malcolm MacCoss, John L. Humes, Stephen G. Pacholok, Theresa M. Kelly et al. SummaryPlus | Full Text + Links | PDF (284 K) | |||
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Novel retinoid X receptor (RXR) antagonists having a dicarba-closo-dodecaborane as a hydrophobic moiety • SHORT COMMUNICATION Kiminori Ohta, Toru Iijima, Emiko Kawachi, Hiroyuki Kagechika and Yasuyuki Endo SummaryPlus | Full Text + Links | PDF (460 K) | |||
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Biological evaluation of novel estrogen-platinum(II) hybrid molecules on uterine and ovarian cancers—molecular modeling studies • SHORT COMMUNICATION Véronique Gagnon, Marie-Ève St-Germain, Caroline Descôteaux, Josée Provencher-Mandeville, Sophie Parent, Sanat K. Mandal, Eric Asselin and Gervais Bérubé SummaryPlus | Full Text + Links | PDF (584 K) | |||
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Identification of peptidomimetic HTLV-I protease inhibitors containing hydroxymethylcarbonyl (HMC) isostere as the transition-state mimic • SHORT COMMUNICATION Hikoichiro Maegawa, Tooru Kimura, Yasuhiro Arii, Yasuko Matsui, Soko Kasai, Yoshio Hayashi and Yoshiaki Kiso SummaryPlus | Full Text + Links | PDF (301 K) | |||
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A nonhydrolyzable analogue of phosphotyrosine, and related aryloxymethano- and aryloxyethano-phosphonic acids as motifs for inhibition of phosphatases • SHORT COMMUNICATION Subashree Iyer, Jarod M. Younker, Przemyslaw G. Czyryca and Alvan C. Hengge SummaryPlus | Full Text + Links | PDF (283 K) | |||
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1,2,3,4-Tetrahydroquinoline-containing αVβ3 integrin antagonists with enhanced oral bioavailability • SHORT COMMUNICATION Shyamali Ghosh, Rosemary J. Santulli, William A. Kinney, Bart L. DeCorte, Li Liu, Joan M. Lewis, Jef C. Proost, Gregory C. Leo, John Masucci, William E. Hageman et al. SummaryPlus | Full Text + Links | PDF (298 K) | |||
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Unprecedented olefin-dependent histidine–kinase inhibitory of zerumbone ring-opening material • SHORT COMMUNICATION Takashi Kitayama, Risa Iwabuchi, Shu Minagawa, Fumihiro Shiomi, John Cappiello, Seiji Sawada, Ryutaro Utsumi and Tadashi Okamoto SummaryPlus | Full Text + Links | PDF (275 K) | |||
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Editorial board • EDITORIAL BOARD PDF (321 K) | |||
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Contributors to this issue • INDEX PDF (188 K) | |||
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Instructions to contributors • PUBLISHER'S NOTE PDF (74 K) | |||
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